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KMID : 1137820180390010001
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의공학회지
2018 Volume.39 No. 1 p.1 ~ p.9
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The Effect of Micro-current Electrical Therapy on Muscle Atrophy and Delayed Wound Healing Process Induced rat Caused by Traumatic Peripheral Nerve Injury
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Lee Han-A
Kim Seo-Hyun
Hwang Dong-Hyun
Yoo Lee
Yu Ji-Hee
Kim Min-Ju
Cho Seung-Kwan
Kim Han-Sung
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Abstract
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This study was carried out to evaluate the effect of micro-current therapy on muscle atrophy and delayed wound healing process caused by traumatic peripheral nerve injury. For this, twenty-five 5-week-old Sprague Dawley rat were used and assigned to five groups including the normal group (NOR, n=5), the wound group (WD, n=5), the wounded and treated with micro-current electrical therapy group (WD+MET, n=5), the sciatic nerve denervated and wounded group (WD+DN, n=5), and the sciatic nerve denervated, wounded and treated with micro-current electrical therapy group (WD+DN+MET, n=5). In order to assess the changes in length of incisional wound for 12 days and the muscle volume for 2 weeks, the ImageJ analysis of macroscopic analysis and micro-CT data were obtained and analyzed. As a result, significant delay in the process in wound healing were observed and micro-current therapy suppress the postponement of healing process. Furthermore, there were significant changes in muscle volume between electrically treated group and non-treated group. These result shows that electrical stimulation may improve the delayed healing process and muscle atrophy at once.
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KEYWORD
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Traumatic peripheral nerve injury, Muscle atrophy, Wound healing, Micro-current electric therapy, Micro-CT I
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